Autori
Pasquale Palumbo, Marco Vanoni, Valerio Cusimano, Stefano Busti, Francesca Marano, Costanzo Manes and Lilia Alberghina
Abstract
A mathematical model of the G1/S transition is proposed, for the budding yeast Saccharomyces cerevisiae. It is known in biology that such a transition is promoted by multi-step phosphorylation processes leading to the activation of the over 200 G1/S regulon genes. Feedback mechanisms play an active role, since part of the enzymes catalyzing the phosphorylation reactions are expressed by the G1/S regulon. The proposed Mathematical model is a Stochastic Hybrd System, since it merges such discrete features (modeled by means of Chemical Master Equations) with a continuous part related to protein and ribosome concentrations.
The model manages to reproduce a large variety of available experimental data and suggests new experiments (carried out at the University of Milano Bicocca) that further validate the model by means of independent data.
